Trans Health Care – Hormone Therapy (Feminizing)

Androgen Blockers

Cyproterone: Cyproterone belongs to a group of medications known as steroidal antiandrogens. Antiandrogens such as cyproterone block the effect of the hormone called testosterone. This causes a reduction in the production of testosterone in the testicles. It is normally taken once a day at the same time each day.

Spironlactone: This is a peripheral testosterone blocker, it doesn’t stop the production of testosterone, but prevents your body from being able to use it. It is classified as a diuretic and is best taken in the morning or when you awaken each day so as to not disrupt your sleep having to frequently get up and go to the bathroom.


Estradiol 17b is the typical formulation prescribed in Ontario.

This is an Oral medication that is taken once or twice a day depending on your dosage.

1mg tablets are normally purple in color, but could vary by manufacturer.

2mg tablets are normally green in color, but could vary by manufacturer.

Are these Medicines Covered by Ontario Drug Benefits?

All of these products are currently covered by the Ontario Drug Benefit including If you are a recipient of Ontario Works (OW), Ontario Disability Support Program (ODSP), or are under 25 years/over 65 years of age and have no other coverage. Interim Federal Health will also cover the cost of some of these medicines if you are a newcomer to Canada after consultation with your healthcare practitioner. If you have private insurance such as Green Shield, Blue Cross, Sun Life etc., you need to refer to your individual plan for coverage levels. If you have none of the above, you would have to be prepared to pay for it out of pocket.

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